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Leukapheresis is a laboratory procedure to separate white blood cells from a sample of blood which can occur with chronic lymphocytic leukemia (CLL). Leukapheresis is a good treatment option for patients who have very high white blood cell count or to obtain white blood cells for later transplant to treat decrease in white blood cells during chemotherapy. It also helps fightingprostate cancerand other form of cancers.

Earlier, leukapheresis was designed for palliative treatment for leukemia with only limited efficacy. But later as this technique was used for treatment modality for hyperleukocytic acute myeloid leukemia, and now it is also used to collect granulocytes to transfuse into neutropenic patients with bacterial or fungal infections, the growth of adoption of this technique is expected to increase.

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How Leukapheresis is important for CAR or Adaptive Cell Therapy Manufacturing?

Chimeric antigen receptor(CAR) T cell therapymay be offered to people when their cancer comes back. Leukapheresis is the first step in this treatment. Research is going on for this treatment. Researchers want to collect T cells from people who may become eligible for a CAR T-cell study in the future. Leukapheresis is an essential step for CAR therapy or other adaptive cellular therapy products. The procedure is required to develop a streamlined process where patients have to undergo apheresis for development of a CAR cell or other adoptive cell therapy product. Once patient meets the eligibility conditions for one of the NCI CAR clinical cell therapy trials, they will undergo leukapheresis estimated by recipient weight and target cell harvest dose in Department of Transfusion Medicine (DTM). Therefore, need for leukapheresis in CAR therapy is a major factor for the boost in its adoption.

Prevalence of Leukemia Is projected to Boost the Treatment

Cases of leukemia have been increasing significantly. According to American Cancer Society, in 2020, there were 60,530 new cases of all kinds of leukemia which witnessed 23,100 deaths. Acute myeloid leukemia being the most prevalent accounted for 19,940 cases in US. The cancer burden in Europe is estimated to have risen to 2.7 million new cases and 1.3 million deaths in Europe as per the Joint Research Centre in European Union. Therefore, it is expected that the rising cases of leukemia and cancer may pave a way of growth for leukapheresis.

Side Effects of Leukapheresis may restrain the Growth

Like any other medical treatment, leukapheresis also have some risks and side effects which may decline its growth. Hypocalcemia, anemia, local or systematic infections may occur among the patients. Hypocalcemia is an irregular drop of calcium from the body when white blood cells are extracted. The lack of calcium in the body may cause numbness, muscle spasms, etc. Anaemia can also occur due to low count of red blood cells or platelets which may happen during the process. Although, in most of the cases, the effect of anaemia is mild. Local or systematic infections, redness and bruising at the vein puncture may also happen. All these side effects can cause the patients to decline the treatment if it is not very important.

Alternative Technologies may Cause Hindrance in Market Boost

As per the research article by pnas.org, clinical leukapheresis can concentrate mononuclear cells from almost the entire blood volume, but such large numbers and cell concentrations are incompatible with such technology. Therefore, an ultra-high throughput microfluidic chip, CTC-iChip rapidly sorts through an entire leukapheresis product of over 6 billion nucleated cells, increasing the CTC isolation capacity by two orders of magnitude. CTC based liquid biopsies provide cancer diagnostics, treatment selection, and response monitoring. Therefore, these factors may cause restrain to the leukapheresis market during the forecast period.

Competitive Landscape

Prominent players in the market include Caltag Medsystems Limited (UK), BioIVT (US), Asahi Kasei Medical Co. Ltd. (Japan), Terumo BCT, Inc. (US), MEDICA S.p.A (Italy), StemExpress, LLC (US), AllCells, LLC (US), Charles River Laboratories (US), Lonza Group AG (Switzerland), Macopharma SA (France), PuriBlood Medical Co. Ltd. (Taiwan), Miltenyi Biotec (Germany), ZenBio (US), Discovery Life Sciences (US), Intelligent Tissue Group (US), Haemonetics Corporation (US), etc.

AllCells, LLC, a leading provider of prmary cells supporting biomedical research announced in September 2020 about the addition of Cyropreserved Leukppaks to their extensive product portfolio. The primary cells are of high quality due to on-site facilities. These cells are cryopreserved using GE Healthcares GMP-compliant VIA freeze quad controlled rate freezer which is capable of consistently high post recovery and viability. Cryopreserved cells are flexible and thus, experiments on them can be done as per the schedule without waiting on delivery of fresh cells.

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Novartis in October 2020 announced the authorization from Japans Ministry of Health, labour and Welfare for a site for manufacturing of commercial CAR-T cell therapy for patients in Japan. The commercial is the first to get approval in Asia. The companys aim is to being treatment closer to patients. Kymriah is the first ever FDA approved CAR-T cell therapy, and the first ever CAR-T to be approved in two distinct indications. Kymriah is currently approved for the treatment of pediatric and young adults of acute lymhoblastic leukemia.

Haemonetics Corporation, Boston based company have made an agreement to sell its Fajardo, Puerto Rico manufacturing operations to filter GVS. The company will retain all intellectual property rights to its proprietary blood filters which are currently manufactured at their Fajardo facility. The company has offered exclusive rights to manufacture and supply the blood filters. Thus, Fajardo facility will become GVS employees.

Regional Outlook

The major contributors towards the growth of leukapheresis include, increasing incidences of leukemia, growing demand for leukapheresis procedures, research applications, growing demand for leukopaks for research applications, etc.

North America is expected to hold the dominating share owing to rise in geriatric population, increasing cases of leukemia. According to Leukemia and Lymphoma Society, approximately every 3 minutes, one person is diagnosed with leukemia in US and in 9 minutes someone dies. According to American Cancer Society, 60,530 new cases of all kinds of leukemia were diagnosed in 2020 which witnessed 23,100 deaths. Acute myeloid leukemia is the most prevalent and accounted for 19,940 cases in US. North Ameirca is one of the leading countries to record deaths due to cancer and leukemia. Furthermore, research and development and new technological advancements are another factor for the market growth.

European region is also expected to have a significant growth during the forecast period 2021-2031. The acute promyelocytic leukemia which is a rare disease also accounted for 2.5 per million person in Italy, 1.39 per million in Spain, 0.54 per million in Great Britain, 0.4 per million in France according to frontiers.org. Growing AML cases are also the concerning topic, it is expected that the cases will increase by 17% by 2027, therefore increasing the growth of its treatment options. All these factors offer a contribution towards the growth of increasing leukapheresis market.

In Asia, China and Pakistan account for 36.2% and 43.5% in AML cases. Increasing medical infrastructure, emerging technologies, increasing trials and investments due to rising geriatric population, and cases of leukemia is paving the way for market growth. As per Globocan, over 20,000 new cases of childhood blood cancer are detected in India of which almost 15,000 cases are of leukemia. China is expected to witness increase over 14,000 cases of acute lymphocytic leukemia by 2029, therefore, rising incidences are projected to grow the adoption of leukapheresis.

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Leukapheresis Market Dynamic Demand and Drives with Forecast to 2031 - Digital Journal

In a shifting real estate market, the guidance and expertise that Inman imparts are never more valuable. Whether at our events, or with our daily news coverage and how-to journalism, were here to help you build your business, adopt the right tools and make money. Join us in person inLas Vegas at Connect, and utilize yourSelect subscriptionfor all the information you need to make the right decisions. When the waters get choppy, trust Inman to help you navigate.

For blockchain technology to gain widespread adoption in an industry as large as real estate, a lot has to play out first.

The prices of blockchain assets are crashing, the processes remain complex, and the U.S. government is eyeing new regulations of and even its own alternatives to the existing slate of private cryptocurrencies.

But some real estate professionals believe the fall of a variety of private tokens may only speed up the process of finding the winning products that could revolutionize the home transaction.

Teresa Grobecker of Grobecker Holland International and Kevin Cottrell of eXp Realty will join a panel at Inman Connect Las Vegas in August to discuss their independent firm Real Estate Consortia and its work to standardize the role of the blockchain in home transactions.

These two and their colleague Sheila Fejeran of eXp all real estate practitioners and executives at Consortia joined Inman on a video call in advance of the conference. Their responses below have been edited for length and clarity.

But first, because this is a confusing and quickly evolving space, lets cover a few terms.

Now, on to Inmans conversation with Consortia.

Inman: In January at Inman Connect New York, Teresa said that replacing intermediaries such as real estate agents is one of the explicit goals of many blockchain enthusiasts. What role might Consortia play in keeping the agent at the center of a blockchain-assisted transaction?

Grobecker: This was my promise to the industry in 2018, jumping off into the national stage. I had no idea what I was getting myself into. I didnt even know Inman and all these things existed. I knew the publication, but events I knew nothing about anything about this space. At the [Real Estate Standards Organization] stage in 2018, I said the promise was to keep the Realtor at the center of this. So when we mint a property nonfungible token, there has to be a practitioner who is the steward to whoever is coming onto the system, to tie that property to the right person. The reason being is, its a relationship-built conversation.

Cottrell: If you look at history, we went through this the first time with the Internet, where people thought that what Expedia did to travel agents was going to happen with real estate agents. And it didnt, because what people realized is, clients want representation. So just introducing blockchain into it doesnt obviate the need for relationships, as Teresa just described. In the Web3 world, or decentralized world, they like to just wipe it clean, and thats just not practical. The expectation is, the efficiency of blockchain will be able to take advantage of what Consortia provides. And if anything we can drive costs out of the transaction, and make it much more efficient, but it doesnt break that linkage [between parties]. We can provide the private blockchain to all of the parties, and still have the public-facing portions that are needed, and do it in a way that youre going to see big adoption in the real estate ecosystem.

One use of the blockchain youve mentioned is hosting a public database of home listings and transactions. Are you describing a competitor of MLSs? And how far are we from seeing it come about?

Grobecker: There is no intention to disrupt the MLS world. I think even when we first launched, there was a lot of fear. Ive been asked this question for the last four years since joining organized real estate. People see a platform where data is shared and the most akin thing we can analogize that onto is MLS. The MLS, I say, is the backbone of financial markets, and at a global scale. The reason why American real estate is so stable is because of the way that the data is collected and stored in the MLS. Consortia has no interest in replicating that system. People have come to me from the MLS world, and they have said, Teresa, consult us on how we would rebuild this on blockchain. It is inefficient, at best. The other side of it is the sales and servicing side of the MLS. We have no intention of going there, so that said, Consortia supplements the kind of data that is available in the housing market, and it puts it in one place.

Fejeran: As she was describing, Consortia is not meant to take over the MLS, or take over the Realtors, or take over any part of the industry. Consortia is to help be a store of data in a more efficient, effective, consistent way of correct information that all parties getting involved in the information will know its true, verified, appropriate, privately held what is appropriate, publicly facing what is appropriate.

How much of Consortias business is as a store of data vs. as an educational resource for agents and others about the blockchain?

Grobecker: Blockchain as a technology enables so many doors to open, and all of a sudden we as practitioners are now dealing with things that have never been on our radar before. So we now have to understand the convergence of SEC laws. We have to know the U.S. Treasury Department financial crimes, their department. That touches on anti-money-laundering laws, and know-your-customer rules. Now we have to say, heres someones crypto wallet. Oh, by the way, wheres this money coming from? Is it coming from the dark web, and the Silk Road? Or is this legitimate funds from someones legitimate wallet? We have to know, are we selling real estate now, or are we selling an SEC-regulated security? For me as a practitioner, especially as a broker, its understanding the convergence of all these laws. I just want to make sure that all my friends stay out of orange jumpsuits. Its really important that theyre all like, OK, these are the laws heres how I stay in my lane and I dont get in trouble.

In recent months, prices of most crypto assets, including NFTs, have undergone a steep decline. Do you think this will affect the timeline for the further adoption of blockchain technology in real estate? Do you think it sets it back?

Grobecker: Forward, actually, and at a rapid clip. And the idea here is that crypto is merely a testing ground for a Fedcoin thats going to be rolled out. And when this project started, that was very conspiracy theory-esque. But the government has since announced that theyre working on Fedcoin. Moreover, in the last couple months, the SEC said they were going to regulate stablecoins. They were going to investigate them, right? And immediately thereafter, stablecoins start to crash. From there, everything starts unwinding, as far as the validity of crypto. And this is actually a beautiful thing. The SEC and the federal government really cracking down is good for the consumer. Them flushing this out is good for the consumer. Its also hardening what will become Fedcoin, and what will become the one or two winners in the actual stablecoin space. So I think everything just moves faster from here in a legitimate, legal way.

Cottrell: I think theres a lot of confusion where people want to equate blockchain with crypto. And thats becoming clear that blockchain is the infrastructure. Its the ledger, if you will; its immutable. That is going to be the infrastructure that moves forward. We may lose 90 percent of the crypto projects. It should remind you of 1999. Over 1999 and 2001, so much went away [in the internet infrastructure]. I expect the same things going to happen to crypto.

Inman Connect Las Vegas kicks off in a little over a month here. Can you give our readers a sneak peak of what you plan to discuss on stage?

Grobecker: As a follow-on to the previous question, probably something thats important to say is the second that Fedcoin or stablecoin, those winners are revealed, 100 percent, all our transactions are on blockchain. So it doesnt matter if you like blockchain, if you hate it thats really irrelevant. Its a matter of, are you ready for it? We as practitioners need to be ready. We need to adapt. We need to educate ourselves, and then be there to service our customers.

Cottrell: Theres a dearth of understanding of the regulatory framework, especially around real estate. Theres a lot of frothy conversations around fractionalization, NFT home sales, and all that. So were going to also touch on that so people understand where we expect the marketplace to go.

Fejeran: The interesting thing is that [a number of influential agents I work with] are hungry for this. They dont understand it, but theyre hungry for it. And theyre hungry for a new application that Consortias going to be doing to sneak peak on the metaverse, since you mentioned it just something that were going to be integrating. Were not going to go into it yet. But just keep your ears out. Thats coming in the future.

Email Daniel Houston

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Will the Fed kill crypto? Real estate agents plot future of blockchain - Inman

What is your biggest memory you associate with Cricket World Cups?

The best and earliest memories that I recollect are that of the World Cup India won in 1983 under Kapil Devs leadership. It was a turning point in the game of Indian cricket where Indian cricket was raised to a different level. Indian cricketers started getting recognition and a lot of respect and it also helped India to make a mark on the world stage.

Since the beginning of the T20 World Cups back in 2007, the event has almost become one of the most awaited festivals in India among fans and brands. What is the first memory you associate with watching T20 World Cups?

My first memory goes back to the 2007 World Cup, the first T20 World Cup that India won in South Africa and the memory was about Mahindra Singh Dhoni trusting the abilities of the young Joginder Sharma who bowled the last ball and managed to get Misbah-ul-Haq out, leading India to victory. It signifies the ability of the captain to take calculated risks and trust his teammates at critical junctures by giving them the ability to shoulder larger responsibilities.

Over the decades weve seen World Cups being one of the premier platforms for brands to launch campaigns that have now been etched in our memories. Any campaign that you recollect from World Cups that you admired the most?

One brand that has leveraged cricket to its maximum is Byjus. The kind of association they have done and their partnerships with ICC and IPL for several years have given them the upper hand to become a household name. They have gained the trust and recognition in every Indian household which gives them a significant increase in their branding prowess.

Through the years, weve seen cricketers - Indian and foreign - become household names with their exhilarating performances in World Cups and leagues like IPL. Who is your all-time favourite T20 cricketer and who are you looking forward to seeing the most in the upcoming T20 World Cup in October?

My favourite T20 cricketer is called the Universal Boss and Chris Gayle is my all-time favourite because he was possibly born to play this format and literally destroyed the careers of so many bowlers around the world.

With the ICC WT20 2022 around the corner and with an IPL recently concluded, which nation according to you holds the edge in winning the coveted championship?

Australia is the defending champions. They won the previous World Cup in 2021 in the UAE and they have it in them to win again. Team Australia also has the advantage of playing on their home grounds which is a plus.

I would like to see Australia win the upcoming T20 World Cup as a tribute to the three cricketing legends we lost recently Shane Warne, Rod Marsh, and Andrew Symonds.

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Playing T20s is a part of my weekly routine, personally excited for the T20 World Cup - Exchange4Media

BEAVERTON, Ore., June 27, 2022 NIKE, Inc. (NYSE:NKE) today reported financial results for its fiscal 2022 fourth quarter and full year ended May 31, 2022.

NIKEs results this fiscal year are a testament to the unmatched strength of our brands and our deep connection with consumers," said John Donahoe, President and CEO, NIKE, Inc. Our competitive advantages, including our pipeline of innovative product and expanding digital leadership, prove that our strategy is working as we create value through our relentless drive to serve the future of sport."**

Fourth quarter NIKE Direct revenues grew 7 percent on a reported basis and 11 percent on a currency-neutral basis, led by 25 percent growth in EMEA, 43 percent growth in APLA and 5 percent growth in North America, partially offset by a decline in Greater China. NIKE Brand Digital grew 15 percent on a reported basis and 18 percent on a currency-neutral basis, driven by double digit growth in APLA, North America and EMEA. NIKE-owned stores declined 2 percent on a reported basis and increased 1 percent on a currency-neutral basis.

In this dynamic environment, NIKE's unrivaled strengths continue to fuel our momentum, said Matt Friend, Executive Vice President and Chief Financial Officer, NIKE, Inc. "Two years into executing our Consumer Direct Acceleration, we are better positioned than ever to drive long-term growth while serving consumers directly at scale."**

Non-recurring Items Impacting Comparability in the Fourth Quarter Fourth quarter results contain several non-comparable items, including non-recurring charges recorded in Other (income) expense, net, totaling approximately $150 million, associated with the deconsolidation of our Russian operations, and the transition of our businesses in Argentina, Chile and Uruguay to strategic distributor models.

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NIKE, Inc. Reports Fiscal 2022 Fourth Quarter And Full Year Results - Nike News

It isnt safe to be on the internet, but that is where business comes from these days. Broker Teresa Boardman offers warning signs to look out for and ideas for keeping yourself safer from online predators.

In a shifting real estate market, the guidance and expertise that Inman imparts are never more valuable. Whether at our events, or with our daily news coverage and how-to journalism, were here to help you build your business, adopt the right tools and make money. Join us in person inLas Vegas at Connect, and utilize yourSelect subscription for all the information you need to make the right decisions. When the waters get choppy, trust Inman to help you navigate.

Working with people we meet on the internet has never been safe. It isnt safe to be on the internet either, but that is where business comes from these days.

For years, my social media accounts and my blog has been attracting all sorts. Some of them have been wonderful and amazing people, and others have been totally crazy and maybe even dangerous.

There are occasional harassing phone calls and text messages and a few threats here and there. Sometimes, people, have bad experiences buying or selling houses and are looking for someone to swear at. There is a steady stream of people who send unwanted private messages.

People who seem normal can become seriously unstable when something goes wrong. It is easy for someone to pose as a homebuyer or seller.

Most of the safety systems in place for real estate agents work after the fact. They can be used to make someone aware that we have been murdered or abducted.

The internet is full of fraud and scams, too. I supposed we just get used to it. I get text messages with inquiries about houses we have on the market. They have links in them and are strangely worded.

I have had people call me and ask questions about clients. Once, a reporter called looking for some information about the owners of a house we had listed. He said he couldnt find any contact information for the owners, but he found mine easily.

Most of the phone calls that come in on the business line are spam or scams. I have blocked so many numbers its hard to imagine that anyone can get through. Most of the calls to my direct line are from scam likely and suspected spam.

There are invoices addressed to my company from companies that I never heard of asking for payment for items I never ordered or received. The attached invoices spread malware.

For a time, I was getting fake notices from Amazon about orders I had placed. Most have a phone number to call if there is something wrong with the order. I think they want me to call it and give them a credit card number. Fat chance. The first time I received such an email I signed into my Amazon account, and there wasnt any order.

Sometimes I just copy and paste the subject line of scam email into Google, and I can learn all about the scam. Occasionally, I get a legitimate email that I delete because it looks like a fake.

I stopped getting those blackmail-type emails with threats and deadlines for sending payment in bitcoin to avoid scandal. During tax season the offers of help were supposedly working with the IRS. Calls from fake government agencies are frequent.

I have also been getting a few fake closing notices every week. They are sent to the general email account. They even have warnings on them about wire fraud. The email addresses do not match those of any title company.

Data breaches are frequent these days. Email passwords need to be passphrases and changed often. One company that had a data breach also makes money providing identity theft protection.

Blogs generate a lot of spam too. Every day I get email proposals from people who have content they want me to publish. They circle back and follow up demanding an answer and expecting a response before I block them.

Spam blockers on my blog catch the spam comments with links to properties for sale in foreign countries and advertisements for drugs, gambling and porn.

Unwanted messages come through Facebook and, of course, friend requests from people who are impersonating other people.

There are frequent text messages from persons or companies with leads. I dont think any of them are legitimate, but I will never know because I usually block the number and delete the message.

The internet is on 24 hours a day, which means we can be harassed around the clock. I go offline into do not disturb mode in the evening.

I interrogate the legitimate callers. I ask question after question before I will give anyone information about anything. I am not at all helpful. I wouldnt want to call me.

Meeting people that found us on the internet isnt always safe. People dont just shop for houses on the internet, they shop for opportunities to exploit people financially and commit crimes.

There is very little that is safe about working with the general public online or off. The FTC Consumer website lists common email, phone and text scams.

It can be hard to keep up with the scams. I have found that it is easier if I dont answer the phone, text messages or email. I miss junk mail.

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The internet is a hotbed for criminal behavior - Inman