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New defense mechanism against viruses and cancer identified

ScienceDaily (Feb. 15, 2012) — A team of scientists from the Charité and German Rheumatism Research Center Berlin and the University of Geneva has found a fundamentally new mechanism how our defense system is ramped up when facing a viral intruder. Exploitation of this mechanism in vaccines sparks new hope for better prevention and therapy of infectious diseases and cancer.

"T killer cells" (CD8 T cells) represent an important element of our body's defense system. They have the capacity to specifically identify and kill cells, which harbor viruses and bacteria or form a cancer. T killer cells would therefore represent an important component of yet unavailable vaccines against infections like HIV/AIDS, hepatitis C virus and malaria, and also for the treatment of cancer.

It has been a longstanding observation that there is no match to the overwhelming T killer cell armada, which is triggered when a viral infection invades our body. Scientists had generally accredited this observation to "pathogen-associated molecular patterns" (PAMPs) on viruses and other microbes. PAMPs, i.e. the "foreign look" of viruses, alert so-called "dendritic cells," which serve as policemen coordinating the T killer cell response.

In a report now published in the journal Science, researchers led by Prof. Max Löhning (Charité-University Medicine & DRFZ Berlin) and Prof. Daniel Pinschewer (University of Geneva) describe an additional general mechanism by which viral infection triggers potent T killer cells: "Dying virus-infected cells themselves ring the alarm bells to T killer cells.," Löhning says. Viruses cause infected cells to die, resulting in the release of cell components, which normally are not be visible to the outside -- analogous to an injured individual loosing blood. Such substances, heralding injury when released, are referred to as "alarmins." The scientists found that T killer cells can sense an alarmin called "interleukin 33" (IL-33). IL-33 is contained in cells, which form the scaffold of the T killer cells' home, the spleen and lymph nodes, and is released when such scaffold cells die.

Mice lacking the gene encoding IL-33 failed to form a large T killer cell army upon viral infection. The few remaining cells had very poor fighting skills. Such mice were therefore exquisitely sensitive to several types of viral infections. Conversely, IL-33 could be used to artificially increase the T killer cell army, which was generated in response to vaccination. As Max Löhning and Daniel Pinschewer explain, PAMPs and alarmins apparently have complementary and non-redundant functions in shaping our T killer cell defense: "The "foreign look" of viruses (PAMPs) activates the "dendritic cell" policemen to engage T killer cells. T killer cells, however, remain lousy fighters unless alerted by a cell death in their neighborhood (alarmins)." These new findings could provide a key to effective vaccination against infectious diseases and cancer.

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The above story is reprinted from materials provided by Deutsches Rheuma-Forschungszentrum Berlin, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

W. V. Bonilla, A. Frohlich, K. Senn, S. Kallert, M. Fernandez, S. Johnson, M. Kreutzfeldt, A. N. Hegazy, C. Schrick, P. G. Fallon, R. Klemenz, S. Nakae, H. Adler, D. Merkler, M. Lohning, D. D. Pinschewer. The Alarmin Interleukin-33 Drives Protective Antiviral CD8 T Cell Responses. Science, 2012; DOI: 10.1126/science.1215418

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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New defense mechanism against viruses and cancer identified

Prototype 2’s hypocritical protagonist almost gets in the way of our bloody, murderous fun

Though Prototype 2 explains why its main character gains the ability to shoot tendrils from his arms, it never touches on why the virus that gives him super powers also turns him into an unrelatable hypocrite, while removing all semblance of morality. All of it. Just wrings it on out. Every drop.

It made more sense in the original game. Beyond being the scapegoat for a massive chemical weapon cover-up, Alex Mercer was also sort of a jerk. He amorally killed thousands of civilians on his rampaging quest for the truth, becoming the monster the government made him out to be. It made sense and happened somewhat organically, as he felt like the entire world had turned against him. It also makes sense that, at least for the opening minutes of Prototype 2, he would be the villain – he sort of already was.

Above: Flying between buildings is always fun

James Heller, the protagonist of the sequel, starts off with the best of intentions: to kill Alex Mercer. He believes Mercer responsible for the virus that destroyed New York City (now called New York Zero for some reason), among the casualties being his daughter and wife.

But it didn’t take long for the new hero to find out the truth about the virus and its origins, and within a few minutes of the game’s opening, he’d already tried to kill Mercer, failed, been injected with the virus, transformed into a powerful super-mutant, and dropped his vendetta almost entirely. In under an hour, Heller had gone from trying to kill Mercer to joining him in an uneasy alliance against the mercenary group responsible for the outbreak.

Above: He could cut Wolverine clean in half with those

And when we say he was given powers, boy do we mean it. Your character in Prototype 2 starts off 10 times stronger than your character ends up in nearly any other game. Right away, we were running up walls, throwing dumpsters at helicopters and slashing apart waves of enemies. Seriously. Spider-Man? Hulk? They’ve got nothing on Heller. Even Infamous's Cole MacGrath looks weak next to Heller an hour into the game.

In fact, we were so powerful right out of the gate that we had problems picking out which skills were new and which ones Mercer flaunted around in the original.  Some stood out – like being able to infect an enemy with the virus and throw him like a grenade (called the bio bomb), and the addition of deadly tendrils, which work like Spider-Man’s webs to let us zip to locations – but it’s hard to figure out what is and isn’t new when you’re so damn powerful. Could we flying kick a helicopter to death in the original game? Could Alex Mercer slam the ground and destroy everything around him with powerful spikes? We just couldn't remember.

Above: We could turn him into a bio-bomb and throw him for hilarious effect

While that might sound negative, it’s actually a compliment to how well the developers weaved the new powers and abilities into the already successful Prototype mold. Controlling Heller is an absolute blast. The sense of power is damn near unparalleled, and the abilities the game threw our way made for a tremendously fun time. He might not feel all that different from Mercer right away, but he feels different enough to make things feel fresh. It even makes sense within the game’s canon. Both characters are infected with the same virus, and viruses mutate. That explains why Mercer’s powers manifested the way they did, while Heller’s gave him tendrils and “viral sonar,” which… well, lets him send out a sonar pulse that points him in the direction of guys he needs to kill.

One thing that confuses us, however, is that shortly after the game began, we felt like Heller had become an insane killer. In Mercer’s case we bought it, as he was sort of an enemy of the state, so we didn’t mind when we were able to slaughter civilians. With Heller… we just don’t get it. He’s a father, a husband, and once he finds out who is responsible for the death of his loved ones ,he sets off on a quest to avenge his wife and daughter by… killing thousands of wives, daughters, sons, and husbands? 

Above: If you don't feel like using powers you can just punch dudes in the jaw

Sure, the game doesn’t “make” you do it, but it’s impossible to fight a battle in Prototype 2 without insane collateral damage. Throwing a car at a helicopter will usually end with that helicopter landing on a pile of meaty humans. In the hour we played we really couldn’t identify with him because his actions didn’t make much sense to us. Maybe the finished product will fix this by providing additional context, or explaining why he doesn't see this as being an issue.

Or maybe the Prototype formula dictates that the hero needs to be a jerk. We don't know. We didn't really think we'd end up liking Mercer all that much, and here we are pining over him.

Then again, as long as we’re still playing a super-human mutant with the ability to slaughter thousands of people at a time ,we doubt we’ll be complaining. Not so long as we’re having fun, at least.

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Prototype 2’s hypocritical protagonist almost gets in the way of our bloody, murderous fun

DGAP-News: comdirect bank AG: record pre-tax profit of EUR 108.1m – over 2.6 million customers – dividend proposal of …

comdirect: record pre-tax profit of EUR 108.1m -  over 2.6 million
customers - dividend proposal of 56 cents per share

Quickborn/Frankfurt/Main, 16 February 2012. The comdirect group closed
financial year 2011 with pre-tax profit of EUR 108.1m. This surpassed the
previous year´s figure of EUR 80.9m by a good third, making it the best
result in the company´s history. ´The high level of profitability confirms
the comdirect group´s sound business model and shows that following growth
in recent years it is able to extensively benefit from developments in the
market, ´ says Dr. Thorsten Reitmeyer, CEO of comdirect bank. After-tax
profit stands at EUR 111.8m and reflects a tax refund amounting to some EUR
37m, which relates to appeal proceedings dating back several years.

Shareholders are set to benefit from this positive development and a
dividend of 56 cents per share (previous year: 42 cents) will be proposed
to the annual general meeting. This constitutes a full distribution based
on the operating profit including the interest payments on the tax refund.
The tax refund itself will be partially retained to strengthen equity with
a view to further growth.

The comdirect group generated income of EUR 340.2m (previous year: EUR
290.9m) in financial year 2011. This record figure stems from the increased
number of trades by customers in a volatile market environment as well as
higher market interest rates compared with the previous year. Consequently,
at EUR 182.6m net commission income was up 6% on the previous year (EUR
172.8m) and net interest income before provisions rose by 48% to EUR 150.8m
(previous year: EUR 102.1m). Other income included interest payments of
around EUR 9m on the tax refund.

The increase in total income of 17% was countered by a disproportionately
lower rise in administrative expenses of 11% to EUR 232.1m (previous year:
EUR 210.0m) resulting in part from intensified marketing activities.

At the year-end, the total number of customers in the comdirect group stood
at 2,630,525 and total assets under custody amounted to EUR 41.59bn. In the
B2C business line (comdirect bank AG) the number of customers has increased
by 73 thousand to 1,632,467 since the start of the year. At EUR 24.90bn at
the end of 2011, assets under custody were down on the level at the end of
2010 (EUR 26.32bn). This was due to the decline in the portfolio volume as
a result of price slides on the stock exchanges, particularly in the third
quarter. 1,235,770 customers had a Tagesgeld PLUS (´call money plus´)
account, which is a rise of 105 thousand. The number of current accounts
increased by 127 thousand to 774,518 and the number of custody accounts by
35 thousand to 783,616.

In the B2B business line (ebase GmbH), the number of customers serviced
climbed by 261 thousand to 998,058 compared with the end of 2010 (737,054).
This rise was attributable to the takeover of customers of renowned
partners in the insurance and investment sectors. Furthermore, around 195
thousand Commerzbank customers have been included following implementation
of a partner-specific white label variant in the second quarter. Assets
under custody rose to EUR 16.69bn (year-end 2010: EUR 16.22bn).

The full annual report 2011 will be published on 27 March 2012. The figures
in this press release are unaudited.

Overview

EUR´000                                  2010    Q1/11    Q2/11    Q3/11
Net interest income before            102,074   33,262   37,624   39,352
provisions
Provisions for possible loan losses      -255     -148     -419     -474
Net commission income                 172,772   50,144   40,308   50,262
Other income                           16,311      324      374   -1,852
Administrative expenses               210,028   58,724   52,322   59,092
Pre-tax profit                         80,874   24,858   25,565   28,196
After-tax profit                       59,634   18,235   18,856   20,458

EUR´000                                  Q4/11      2011   2011 vs. 2010
Net interest income before provisions   40,609   150,847           47.8%
Provisions for possible loan losses       -290    -1,331            n.a.
Net commission income                   41,871   182,585            5.7%
Other income                             9,203     8,049          -50,7%
Administrative expenses                 61,936   232,074           10.5%
Pre-tax profit                          29,457   108,076           33.6%
After-tax profit                        54,214   111,763           87.4%

Length:  3,154 characters including spaces, excluding table

All images for the press and analysts´ conference on 16 February will be
available as of 15.00 hrs at http://www.comdirect.de/bildmaterial
All press releases are available at http://www.comdirect.de/pr

If you no longer wish to receive these press releases, please send an
e-mail to presse@comdirect.de.

End of Corporate News

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DGAP-News: comdirect bank AG: record pre-tax profit of EUR 108.1m - over 2.6 million customers - dividend proposal of ...

New Weasel Word on Iran Nukes

Exclusive: The U.S. news media has consistently created the impression that Iran is building a nuclear bomb and that its denials shouldn’t be taken seriously. However, U.S. and Israeli intelligence assessments may finally be eroding that smug certainty, Robert Parry reports.

By Robert Parry

What can one say when the Washington Post’s neoconservative editorial writers more correctly describe the U.S. and Israeli assessments on Iran’s nuclear program than does a news story in the New York Times? In a Wednesday morning surprise, a Washington Post editorial got the nuances, more or less, right in stating: “U.S. and Israeli officials share an assessment that, though Iran is building up nuclear capability, it has not taken decisive steps toward building a bomb.”

Defense Secretary Leon Panetta testifying before Congress, seated next to Chairman of the Joint Chiefs of Staff Martin Dempsey (Defense Department photo)

You could still say the Post is hyping things a bit, skewing the wording in an anti-Iranian direction, but the sentence is essentially correct on where U.S. and Israeli intelligence judgments stand, that Iran has NOT made a decision to build a nuclear bomb.

But then there’s the New York Times. It continues to mislead its readers, albeit with a new weasel word inserted to avoid being accused of completely misstating the facts. In a news article on Wednesday, the Times reported that “the United States, Europe and Israel have all called [Iran’s nuclear] program a cover for Iranian efforts to develop nuclear weapons capability, an accusation that Iran denies.”

The key weasel word now is “capability,” which is a very elastic concept since any work on nuclear research for peaceful purposes, such as low-level enrichment of uranium, could theoretically be used toward a weapons “capability.” (The word also appeared in the Post editorial.)

There’s a parallel here to President George W. Bush’s statements about the Iraq War: Remember, after his promised Iraqi stockpiles of WMD didn’t materialize, Bush retreated to claims about WMD “programs,” i.e. the possibility that something might have occurred down the road, not that it actually had happened, was happening or was likely to happen. “Capability” is now filling a similar role.

So, instead of stating that U.S. and Israeli intelligence agencies concur that Iran’s leadership has NOT made a decision to go forward with a nuclear bomb, the Times creates a false impression that they have done so – by suggesting Iran is making progress toward a “nuclear weapons capability.”

If that wording leaves you with the notion that Iranian leaders have decided to press ahead in building a nuclear bomb (but are lying about their intent), you can be forgiven because that seems to be the misimpression the Times wants you to have. Indeed, even well-informed Americans have come away with precisely that misimpression.

And there’s another parallel to Bush’s case for war with Iraq, when he falsely implied that pre-invasion Iraq was allied with al-Qaeda, without actually saying precisely that. Any casual listener to Bush’s speeches would have made the implicit connection, which was what Bush clearly intended with his juxtaposition of words, but his defenders could still argue that he hadn’t exactly made the link explicit.

Now this sleight of hand is being done mostly by the U.S. news media, including the New York Times in its influential news columns. To state the obvious, employing misleading word constructions to confuse readers is an inappropriate technique for a responsible news organization.

Intelligence Assessments

The Times and most other major U.S. news outlets have refused to alter their boilerplate on Iran’s nuclear ambitions (beyond slipping in the word “capability”), even as a consensus has emerged among the intelligence agencies of the United States – and Israel – that Iran has NOT made a decision to build a nuclear weapon.

As ex-CIA analyst Ray McGovern has noted, this intelligence judgment has even been expressed recently by high-profile figures in the defense establishments of the two countries – U.S. Defense Secretary Leon Panetta and Israel’s Defense Minister Ehud Barak.

In an article entitled “US/Israel: Iran NOT Building Nukes,” McGovern wrote: “You might think that you would have heard more about that, wouldn’t you? U.S. and Israel agree that Iran is NOT building a nuclear bomb. However, this joint assessment that Iran has NOT decided to build a nuclear bomb apparently represented too big a change in the accepted narrative for the Times and the rest of the FCM [Fawning Corporate Media] to process.”

McGovern cited an interview by Barak on Jan. 18 in which the Defense Minister was asked:

Question: Is it Israel’s judgment that Iran has not yet decided to turn its nuclear potential into weapons of mass destruction?

Barak: … confusion stems from the fact that people ask whether Iran is determined to break out from the control [inspection] regime right now … in an attempt to obtain nuclear weapons or an operable installation as quickly as possible. Apparently that is not the case. …

Question: How long will it take from the moment Iran decides to turn it into effective weapons until it has nuclear warheads?

Barak: I don’t know; one has to estimate. … Some say a year, others say 18 months. It doesn’t really matter. To do that, Iran would have to announce it is leaving the [UN International Atomic Energy Agency] inspection regime and stop responding to IAEA’s criticism, etc.

Why haven’t they [the Iranians] done that? Because they realize that … when it became clear to everyone that Iran was trying to acquire nuclear weapons, this would constitute definite proof that time is actually running out. This could generate either harsher sanctions or other action against them. They do not want that.

Question: Has the United States asked or demanded that the government inform the Americans in advance, should it decide on military action?

Barak: I don’t want to get into that. We have not made a decision to opt for that, we have not decided on a decision-making date. The whole thing is very far off. …

Question: You said the whole thing is “very far off.” Do you mean weeks, months, years?

Barak: I wouldn’t want to provide any estimates. It’s certainly not urgent. I don’t want to relate to it as though tomorrow it will happen.

Less Alarming Consensus

In a Jan. 19 article on Barak’s interview, the Israeli newspaper Haaretz summed up the Israeli view as follows: “The intelligence assessment … indicates that Iran has not yet decided whether to make a nuclear bomb.

“The Israeli view is that while Iran continues to improve its nuclear capabilities, it has not yet decided whether to translate these capabilities into a nuclear weapon – or, more specifically, a nuclear warhead mounted atop a missile. Nor is it clear when Iran might make such a decision.”

McGovern noted that Barak in the interview appeared to be identifying himself with the consistent assessment of the U.S. intelligence community since late 2007 that Iran has not made a decision to go forward with a nuclear bomb. The formal National Intelligence Estimate of November 2007 – a consensus of all 16 U.S. intelligence agencies – stated:

“We judge with high confidence that in fall 2003, Tehran halted its nuclear weapons program; … Tehran’s decision to halt its nuclear weapons program suggests it is less determined to develop nuclear weapons than we have been judging since 2005.”

Despite complaints about the NIE from some American and Israeli war hawks, senior U.S. officials have continued to stand by it. Defense Secretary Panetta raised the topic himself in an appearance on CBS’s “Face the Nation” on Jan. 8.

Panetta said “the responsible thing to do right now is to keep putting diplomatic and economic pressure on them [the Iranians] … and to make sure that they do not make the decision to proceed with the development of a nuclear weapon.”

Panetta was making the implicit point that the Iranians had not made that decision, but just in case someone might miss his meaning, Panetta posed the direct question to himself: “Are they [the Iranians] trying to develop a nuclear weapon? No.”

Today, it appears that even the neocon editors of the Washington Post have been forced to accept this important distinction, grudging as that acknowledgement may have been. The New York Times, however, has simply inserted the new weasel word, “capability,” which could mean almost anything and which still misleads readers.

To its credit, perhaps, the Times did include another relevant fact near the end of its Wednesday article, noting that Israel is “a nuclear weapons state.” That’s a key fact in understanding why Iran might want a nuclear deterrent but is rarely cited by the Times in its background on the current crisis.

For further context, the Times also might want to add that Israel’s nuclear arsenal remains undeclared and that Israel – unlike Iran – has refused to sign the Nuclear Non-Proliferation Treaty or to allow international inspectors into Israeli nuclear facilities. But such balance may be simply too much to expect from the Times.

[For more on related topics, see Robert Parry’s Lost History, Secrecy & Privilege and Neck Deep, now available in a three-book set for the discount price of only $29. For details, click here.]

Robert Parry broke many of the Iran-Contra stories in the 1980s for the Associated Press and Newsweek. His latest book, Neck Deep: The Disastrous Presidency of George W. Bush, was written with two of his sons, Sam and Nat, and can be ordered at neckdeepbook.com. His two previous books, Secrecy & Privilege: The Rise of the Bush Dynasty from Watergate to Iraq and Lost History: Contras, Cocaine, the Press & ‘Project Truth’ are also available there.

Tags: Ahud Barak, George W. Bush, Iran, Israel, Leon Panetta, New York Times, nuclear weapons, Robert Parry, Washington Post

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New Weasel Word on Iran Nukes

How To Make Money Online – 4 Proven Website Business Models, Part 4 – How To Build Residual Income – Video

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