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Washington (CNN) -- President Obama weighed in on the Scottish independence referendum Wednesday night when he tweeted in favor of a united UK.

But for the most part, faced with the prospective divorce of its closest friend, the United States is following the advice column carefully: don't take sides, keep your opinions to yourself, and avoid getting dragged into the fray.

The complicating factor in this potential split? One side has a nuclear arsenal. Who gets custody of that?

Thursday's independence referendum in Scotland, and with it the possible split of the 300-year-old United Kingdom, could have consequences big and small, including in the United States. The "special relationship" heralded by presidents and prime ministers for decades would be fundamentally altered, though American officials refuse to speculate in which ways.

As British Prime Minister David Cameron said on Tuesday, a "yes" result on independence would amount to a "painful divorce" between Scotland and the rest of Great Britain, not a "trial separation."

Scotland divided over independence

Scotland divided over independence

Scotland divided over independence

Scotland divided over independence

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Obama picks a side

"Antibiotics are among the most commonly prescribed drugs in medicine," Frieden said. "But either half are not needed or are not optimally prescribed."

"We can help doctors use antibiotics more wisely and can be certain whether our efforts to reduce antibiotic resistance are working," Frieden said.

During a press call to announce the moves, a reporter said that it all sounded like a "very bureaucratic set" of steps, and questioned what the effect on people would be.

Read MoreThe good (and bad) news about employer health plans

"This may sound rather bureaucratic, but it's anything but," said Eric Lander, co-chairman of the President's Council of Advisors on Science and Technology, whose report to Obama called for added spending to address the problem.

"This has been a problem that's been brewing for decades. This is now an [issue] that I think we're all aware requires very serious, coordinated action," Lander said. "What's new here is a real federal focus on this."

Other highlights of Obama's executive order include:

HHS, according to the administration, will soon hold a public meeting to focus the $20 million competition on the types of diagnostic tests most needed for recognizing and treating antibiotic-resistant bacterial infections.

Read MoreAntibiotic-resistant 'superbugs' creep into nation's food supply

The prize will be co-sponsored by the National Institutes of Health and the Biomedical Advanced Research and Development Authority.

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Obama's new battleresistant bacteria

President Barack Obama says a bipartisan Senate vote to authorize arming and training Syrian rebels shows the world that Americans are united in combating the Islamic State group.

Obama says Islamic State terrorists thought they could frighten or intimidate the U.S. through the barbaric murder of two Americans.

He says they're learning the same lesson that others have learned. He says Americans don't give in to fear, but rather pull together and stand together.

Obama says U.S. airstrikes against Islamic State targets will continue. But he says U.S. troops will not have a combat role on the ground in Iraq or Syria.

Obama spoke at the White House shortly after the Senate approved his plan for training and equipping Syrian rebels. The vote clears the measure for Obama's signature.

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Obama: Vote Shows US United Against Islamic State

Al Sharpton: Rand Paul could be a real threat in the general election
Al Sharpton on Weekends w/ Alex Witt - 8/31/14.

By: bxtidre7

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Al Sharpton: Rand Paul could be a real threat in the general election - Video

Sen. Paul Questions Sec. Kerry on ISIS Strategy- September 17, 2014
Sen. Rand Paul questions Secretary of State John Kerry on U.S. ISIS strategy at SFRC hearing.

By: SenatorRandPaul

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Sen. Paul Questions Sec. Kerry on ISIS Strategy- September 17, 2014 - Video