Mediaboss Marketing

PARIS Scientists said Sunday they had found a key piece in the puzzle as to why a tiny minority of individuals infected with HIV have a natural ability to fight off the deadly AIDS virus.

In a study they said holds promise for an HIV vaccine, researchers from four countries noted the secret lies not in the number of infection-killing cells one has, but in how well they work.

Only about one person in 300 has the ability to control the human immunodeficiency virus without drugs, using "killer" cells called cytotoxic T lymphocyte cells, past research found.

Taking that discovery further, scientists from the United States, Canada, Japan and Germany reported that the strain has molecules called receptors that are better able to identify HIV-infected white blood cells for attack.

Until now, it was well known that people with HIV "have tons of these killer cells," said Bruce Walker, an infectious diseases expert at the Ragon Institute in Massachusetts.

"We have been scratching our heads since then, asking how, with so many killer cells around, people are getting AIDS. It turns out there is a special quality that makes them (some cells) better at killing."

The study looked at 10 infected people, of whom five took antiretroviral drugs to keep HIV under control while five were so-called elite controllers who remained naturally healthy.

HIV kills a type of white blood cell called CD4, leaving people with AIDS wide open to other, opportunistic and potentially deadly infections.

"What we found was that the way the killer cells are able to see infected cells and engage them was different," said Walker.

"It is not just that you need a killer cell, what you need is a killer cell with a (T cell) receptor that is particularly good at recognizing the infected cell. This gives us a way to understand what it is that makes a really good killer cell."

More:
HIV has natural-born killers, researchers find

Today, Microsoft executives are making a major announcement at a press event so secretive they waited until the day of just to reveal the location (Milk Studios in L.A.). Here's the best and rest of the event.

Late last week, Microsoft invited a handful of tech reporters to Los Angeles today for an event that boasts all the shrouded mystique of an Apple keynote. (At press time, reporters hadn't yet received word of the location.) Apple, of course, has mastered the art of hyping press events that stir the vat of consumer desire like little else in the tech world. The similarly frenetic rumor mill is churning out all kinds of speculation on today's pending Microsoft announcement. We'll be following the best of the day's news here, both live from the event and from around the web.

Check back here throughout the day for the latest Microsoft news. For live dispatches from the 3:30 p.m. PST/6:30 p.m. EST event, follow Austin Carr on Twitter.

[Image: Flickr user Lesley Middlemass]

View original post here:
The Best Of Today's Mysterious Microsoft Announcement

NEW YORK The White House messed up its history. That's the contention of critics who pointed to references recently appended to the biography pages of past presidents on the White House website.

Scholars of Calvin Coolidge, the president who is our focus, found an error. The Coolidge "Did You Know?" item says that "On Feb. 22, 1924, Calvin Coolidge became the first president to make a public radio address to the American people."

Alas, Coolidge was not the first, as a retired archivist with the National Archives and Records Administration, Jerry L. Wallace, noted in an email to us. The first chief executive to deliver a radio address was Warren G. Harding, whose dedication of the Lincoln Memorial was carried over the airwaves on May 30, 1922.

What the Barack Obama White House did was introduce its own comments and facts to the extant biographies of the presidents on the White House pages. Some commentators such as Seth Mandel at Contentions, the Commentary magazine blog, interpret the effort to draw such parallels as an intrusion on past presidents.

Mandel sees the Obama administration comments as evidence that the president, like many of his young devotees, doesn't "have much memory of the political world before the arrival of The One." You can agree or disagree with this criticism.

The real story here is not the specific Coolidge error or whether you like the new White House comments. It is that accurate history is becoming much harder to deliver than it used to be.

The Internet and databases have raised the bar for all writing on history. Your authors, both students of Coolidge, discovered this firsthand in researching an iconic quote long attributed to Silent Cal.

Coolidge endured severe setbacks in life. Yet he persevered. The Coolidge quotation that captures that perseverance best was printed in a pamphlet in the 1930s by New York Life Insurance Co., where the 30th president served as a director:

"Nothing in this world can take the place of persistence. Talent will not; nothing is more common than unsuccessful people with talent. Genius will not; unrewarded genius is almost a proverb. Education will not; the world is full of educated derelicts. Persistence and determination alone are omnipotent. The slogan 'press on' has solved and will always solve the problem of the human race."

To say this quotation is loved is an understatement. Historians have routinely slammed anyone who dared suggest it was not uttered by Coolidge.

Follow this link:
Calvin Coolidge persisted in deed, if not in word

Wow, it's already just about halfway through June.

It seems like just yesterday that we were talking about the primary results. And, well, we are still talking about the results in a couple of races.

These include the Democratic primary in Senate District 30, where there is an update in the Word from the Maxine Velasquez campaign.

And, of course, there are still those fires that are still raging in southern New Mexico. It would be nice to have those monsoons come through -- without the lightning that, spectacular as it may be, would be very dangerous in these very dry conditions.

On to the Word:

We won on election night, they won tonight, but there is still a long way to go until the recount on June 26th," Velasquez said. "I feel confident well come out on top in the end." Yup, a recount is acomin'.

The board revoked the license for La Mesa Racetrack and Casino in Raton because developers failed to open the casino by May 2010 and didn't show they had adequate financing to complete the racetrack.

In order to cope with the influx of a younger workforce, Jeff Aronoff created D:Hive, a community and business hub in downtown Detroit that serves as a one-stop shop for young people in the city. As executive director, Aronoff assists them with job, housing and quality-of-life resources. Like many of Detroits other economic development initiatives, D:Hive, which formally launched last month, is funded primarily by a grant from a local foundation (in this case, a three-year, $1.2 million grant from the Hudson-Webber Foundation).

Foundations, supported largely by money from the once-booming auto industry, are still a mainstay in southeast Michigan.

Look, we want to end the wars now. We want to bring home our troops from Afghanistan. We want to balance the federal budget now. We need to reform entitlements now. We want to repeal the Patriot Act. We want to bring an end to the drug war. Marriage equality is a good thing," he says according to the press release. "I am socially tolerant and I am fiscally responsible. I am the average American. I want to be represented.

Go here to see the original:
Morning Word, 06-14-12

LONDON, June 18, 2012 /PRNewswire/ --

- A top destination for Holiday Hypermarket travellers this year is Palma, Majorca, in the Balearic Islands -

One of the most popular destinations among Holiday Hypermarket customers this year, Majorca has morphed from an island of package holidays to 'treasure island' for British summer holidaymakers.

Also fashionable among other nationalities, Majorca's airport fields flights from Germany, Italy, Portugal, the Netherlands and Sweden, and is a "rare profitable operation" for its body corporate, Spanish Airports and Air Navigation, which is increasing the number of routes to the island.

But the holiday island in the Balearics is not just a haven for budget travellers. According to a recent survey, Majorca and the nearby clubbing destination of Ibiza are two of ten locations in the world where holidaymakers are most likely to bump into celebrities.

Considering members of the Spanish royal family spend their holidays at the Marivent Palace in Majorca, and actors Michael Douglas and Catherine Zeta-Jones own a Majorca mansion, while Claudia Schiffer, Andrew Lloyd Webber and Rafael Nadal - who was born there - have homes on the island, there's plenty of glamour to go around.

Calum MacDonald, Marketing Manager at Holiday Hypermarket comments, "Majorca has had a stylish makeover in recent years when many of the buildings were renovated and green spaces were expanded. Not to mention its unspoilt beaches, which are wide and golden, and close to luxury accommodation; it's a great place to spend a summer holiday."

About Holiday Hypermarket:

Holiday Hypermarket (http://www.holidayhypermarket.co.uk/) is a UK based holiday comparison community. We are passionate about helping people in the UK explore, learn and enjoy the world by removing the obstacles that keep them from getting the most out of their holidays. We do this by providing a completely independent travel comparison site that allows you to effortlessly find the best deals with the assistance of a knowledgeable community of fellow travellers who love to share travel advice.

With Holiday Hypermarket you have access to a huge number of travel suppliers which will help you put together flexible, restriction free, itineraries. This, combined with our excellent customer service and vibrant online community, makes Holiday Hypermarket a great place to start exploring the world.

Read more from the original source:
Treasure Island: Palma in Majorca is Trumps for Holiday Hypermarket Travellers