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Youniversalstar – For artists, entertainers, and their fans – Video


Youniversalstar - For artists, entertainers, and their fans
Youniversalstar.com is a new social networking site designed to allow artists and entertainers to promote themselves and their work. Register on youniversalstar.com now to receive updates and promotions. Like and follow on Facebook and Twitter

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Youniversalstar - For artists, entertainers, and their fans - Video

New Facebook Tool, Te'o Scandal Fan Flames of Privacy Debate

Social networking platforms are becoming increasingly sophisticated in culling information from users, inadvertently fanning the flames of new privacy debates.

Earlier this week, Facebook rolled out a new social search tool that lets users gather content that other users have already shared on their Facebook profiles, such as relationship statuses, news, music and eating habits. Graph Search is being billed as a powerful tool to help people refine searches for public information, or locate others who share their interests.

(Read More: Facebook Rolls Out Social Search Feature.)

Yet analysts note that Graph's evolution could eventually allow Facebook to challenge dating websites and other search engines. Some experts say those moves raise more thorny questions over user data, in a sector beset by widespread privacy and fraud jitters.

"It's fair to question the common narrative that because [Graph] Search respects privacy settings, then there aren't privacy issues,"said Woodrow Hartzog, a law professor and affiliate scholar at the Center for Internet and Society.

Hence why Facebook's new search tool comes with both risks and rewards. The more refined search capabilities of Graph could "substantially increases the probability that some [users] will actually see aw hole trail of information that you thought was tucked away in some dark corner of Facebook," according to Hartzog.

"Certainly that is a great feature, but we've seen some really harmful things happen when privacy settings are not respected," he added.

As debates erupt over how social networks can repurpose user information for profit, it also raises the specter of ordinary users using the same tools for nefarious purposes which run the gamut from bothersome fundraising appeals from Nigeria, and dating hoaxes.

Facebook's Social Graph's arrival coincides with a scandal involving an NFL-bound college football star and an online romance gone wrong.

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New Facebook Tool, Te'o Scandal Fan Flames of Privacy Debate

La Jolla Institute Identifies Molecular Switch Enabling Immune Cells to Better Fight Disease

-- Finding on Killer Cells Opens New Avenue for Combating AIDS, Cancer and other Diseases

Newswise SAN DIEGO (January 20th, 2013) A research team led by the La Jolla Institute for Allergy & Immunology has discovered the mechanism that enables CD4 helper T cells to assume the more aggressive role of killer T cells in mounting an immune attack against viruses, cancerous tumors and other damaged or infected cells. The finding, made in collaboration with researchers from the RIKEN Institute in Japan, could enable the development of more potent drugs for AIDS, cancer and many other diseases based on using this mechanism to trigger larger armies of killer T cells against infected or damaged cells.

CD4 helper T cells, which normally assist other cells of the immune system during an infection, and CD8 killer T cells, which directly attack and eliminate infected cells, are two of the bodys most important immune cells for defending against diseases. Earlier research studies have shown that helper T cells can become killer cells in some instances. However, the specific mechanism of action that allowed this to occur was not known until now.

We have identified the molecular switch that enables CD4 T cells to override their programming as helper cells and transform into cytolytic (killer) cells, said La Jolla Institute scientist and study co-leader Hilde Cheroutre, Ph.D. Our team also showed that these transformed helper T cells represent a separate and distinct population of cells. They are not a subset of TH-1 helper cells as previously thought.

Jay A. Berzofsky, M.D., Ph.D., chief of the Vaccine Branch at the National Cancer Institutes Center for Cancer Research, called the finding a major advance that provides new understanding about the cells lineage and basic mechanisms. Dr. Berzofsky was among the researchers whose work in the 1980s first demonstrated that helper cells could convert to killer cells. Understanding how these cells derive and what causes them to switch from helper T cells to cytolytic T cells is an important step to learning how to manipulate them in disease, he said, noting it could lead to novel approaches either to turn these cells off in autoimmune disease or turn them on in infectious diseases.

He added that the finding could also have important implications in cancer. We need all of the cytolytic machinery that we can get to try to destroy cancers, he said. If we can learn to turn them on, I think its reasonable to believe that these cytolytic T cells can play an important role in controlling cancer.

The findings were published today in Nature Immunology in a paper entitled Transcriptional reprogramming of mature CD4 helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes. Dr. Cheroutre is co-senior author on the study together with Dr. Ichiro Taniuchi of the RIKEN Research Center for Allergy and Immunology in Yokohama, Kanagawa, Japan. First authors on the paper are: Mohammad Mushtaq Husain, Ph.D., of the La Jolla Institute; Daniel Mucida, Ph.D., formerly of the La Jolla Institute, now at Rockefeller University; Femke van Wijk, Ph.D., formerly of the La Jolla Institute, now at the University Medical Center Utrecht, The Netherlands, and Sawako Muroi, of the RIKEN Institute.

Mitchell Kronenberg, Ph.D., La Jolla Institute president & chief scientific officer, said the study reflects the very successful collaboration between the La Jolla Institute and RIKEN in Japan, which have joined efforts on a number of projects over the years.

In the study, the researchers found that a certain transcription factor, which are molecules in the cell nucleus that control the activity of cells, continually suppresses the killer T cell lineage in helper T cells. Using mice, the team showed that turning off this transcription factor (ThPOK) enabled the helper cells in the bodys peripheral areas, like the blood, spleen and the intestine, to override their original programming and to become killer T cells. While our work focused on the intestines, we found that helper T cells in all tissues of the body have the potential to become killer cells in response to recognition of viral, tumor or other antigens in the context of cytokines such as IL-15, said Dr. Cheroutre.

Jonathan Braun, M.D., chair of the Department of Pathology and Laboratory Medicine at UCLAs David Geffen School of Medicine, praised the study as laying the groundwork for using T helper cells in a much more aggressive manner. Helper T cells are mainly understood for their role in regulating other immune cells, he said. This work reveals how they themselves can be triggered to become the action cells in the immune response. This opens new possibilities for how to manipulate them therapeutically in disease.

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La Jolla Institute Identifies Molecular Switch Enabling Immune Cells to Better Fight Disease

How to configure the Fox Contact Form in Joomla 2.5 – Video


How to configure the Fox Contact Form in Joomla 2.5
The Fox Contact Form is simple to set-up and configure in Joomla 2.5. Follow this simple brief overview to get a better understanding on how to get your Joomla form up quickly.

By: Richard Bankert

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How to configure the Fox Contact Form in Joomla 2.5 - Video

Twitter Bootstrap 2.2.2 Tutorials Lesson 2 – Creating a Homepage – Registration Form – Video


Twitter Bootstrap 2.2.2 Tutorials Lesson 2 - Creating a Homepage - Registration Form
In this web development video we twitter bootstrap form controls to add a registration form to the modal window. Suggested Text Editors: Notepad++ (free) - notepad-plus-plus.org Sublime Text 2 (free unlimited trial, licensed version $59) - http://www.sublimetext.com Link to Bootstrap 2.2.2: http://www.twitter.github.com Connect with easydevtuts - twitter.com http://www.facebook.com plus.google.com More web development tutorials coming soon: -convert PSD files to Joomla and WordPress templates -create Joomla and WordPress templates with Bootstrap and PHP - and much more!

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Twitter Bootstrap 2.2.2 Tutorials Lesson 2 - Creating a Homepage - Registration Form - Video