Mediaboss Marketing

A digital marketing company which lured some of the brightest brains in the business from Leeds back to Hull is bucking the trend again by expanding under lockdown with new recruits and new clients.

43 Clicks North opened its office at The Deep Business Centre in Hull in August 2019 with just five people, and as numbers grew managing director Mike Ellis made the decision to find the company a new home all to itself.

The complications of COVID-19 were such that by the time the company left The Deep in November 2020 it had a workforce of 12, all working from home.

But the recruitment continued, and by the time 43 Clicks takes the keys for its new office in the Old Town of Hull next month it will have 17 people with more on the way.

It will also have a work-from-home strategy which is likely to take the complement of staff beyond the planned capacity of the building.

Ellis said: Weve taken on five new people since we left The Deep, and four of those have joined since the start of this year.

We expect to hire another two or three after we occupy the new building in April and we think well be able to fit about 35 in there but with a rota which enables us to have a few more on the payroll.

Two of the recent recruits have joined from other tech firms in Leeds and are likely to stay in their home city and work remotely. Others have relocated from West Yorkshire to East Yorkshire, as Ellis and his colleagues did when they arrived at The Deep.

The expansion has been driven by the companys success in securing deals with seven new clients since November.

Ellis added: We came back to Hull to work and to build a digital community and weve surprised ourselves we thought that 20 people would be enough and we would hit that level and stay at The Deep.

But we found somewhere just for us because the business kept growing with new business and up-sales we exceeded our turnover from last year in just over three months from our year-end in November.

:::

Digital marketing agency Ascensor is scaling up its digital apprenticeships in partnership with The Coders Guild.

It is also creating ten leadership and management apprenticeships, delivered through Pareto.

MD Andrew Firth said: Training and development is a vital part of Ascensors business philosophy and growth strategy.

We develop and build Ecommerce websites and apps for successful businesses.

The digital sector is fast moving, and we always want to demonstrate that we are at the leading edge when it comes to the skills of our people.

Over recent years, Leeds-based Ascensor has supported many interns, undergraduates and apprentices across all areas of their business, including technical development, digital marketing and business development.

It is working with The Coders Guild to support its recruitment and training of developers and testers.

Firth added: The Coders Guild is a well-respected training provider with nine years experience designing and delivering high quality digital training.

They have helped to create national standards for digital apprenticeships, and we are delighted to be working with them.

The Coders Guild will help us to deliver and accredit our Level 3 and Level 4 Apprenticeship programmes. Our involvement with them dovetails perfectly with our current recruitment for a trainee website tester.

The agency is also providing leadership and management apprenticeship training for five team leaders, with another five planned in six months time. It is delivering these programmes in partnership with Pareto.

Firth said: We want to equip our team members with the skills to become the team leaders and managers of tomorrow.

We chose Pareto because their Operational Management Apprenticeship programme is designed to deliver the core competency requirements in a range of important areas, such as leading and managing people, communication, operational management, and performance management.

Since 80% of the learning is undertaken on the job, this is a relevant and valuable skills programme for our people.

:::

Leeds-based digital-first creative agency Rascal has expanded with the appointment of two senior roles to the team.

In a newly created position, Stephanie Pullen joins as head of digital strategy.

Previously with Brilliant Agency where she worked across creative strategy for clients including Very Lazy, Newmans Own, Yorkshire Provender and Mighty Pea; Pullen is now responsible for coordinating the overall strategic direction and growth of Rascal.

JJ Amos has taken up the head of design role, overseeing the execution of all campaigns and client work across creative, copywriting and videography.

Amos has previously held senior design and art director roles at agencies including Brilliant and Twentythree04.

Rascal founder, Joe Costandi, said: Im so pleased to have JJ and Steph as part of the Rascal team. Were in a strong growth phase and these positions are vital to our business, putting us in a perfect position to push ourselves even harder on our ambitious plans.

JJ and Steph bring a wealth of ideas and creativity with them and will be working with me to strengthen the team over the coming months.

:::

Consumer electronics company, Casio, has appointed performance marketing agency Journey Further to handle its performance marketing activity.

The appointment will see Journey Further, which has offices in Leeds, Manchester and London, manage PPC and SEO for the Japanese brand, with a focus on growing consumer sales of its timepiece range, including the iconic G-Shock watch.

The agencys remit will also include driving sales for Casios range of musical instruments and calculators.

Danny Power, ecommerce and digital manager at Casio, said: We are in a process of digital transformation and as such weve grown significantly in this area over the past few years.

We appointed Journey Further to supercharge our search growth and they impressed us with their flexible, data-driven approach. Its been a fantastic start to the partnership.

Chris Rowett, paid media director at the agency, said: Were really excited to be working with Casio, a brand with a fantastic range of products that are sold all over the world.

Our strong ecommerce experience combined with our data-led approach provides the perfect platform to help grow Casios consumer sales across a number of different products.

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Agency roundup: 43 Clicks North; Ascensor; Rascal Creative; and more | TheBusinessDesk.com - The Business Desk

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Honeywell expects that as advances in quantum computing continue to accelerate over the next 18 to 24 months, the ability to replicate the results of a quantum computing application workload using a conventional computing platform simulation will come to an end.

The companys System Model H1 has now quadrupled its performance capabilities to become the first commercial quantum computer to attain a 512 quantum volume. Ascertaining quantum volume requires running a complex set of statistical tests that are influenced by the number of qubits, error rates, connectivity of qubits, and cross-talk between qubits. That approach provides a more accurate assessment of a quantum computers processing capability that goes beyond simply counting the number of qubits that can be employed.

Honeywell today provides access to a set of simulation tools that make it possible to validate the results delivered on its quantum computers on a conventional machine. Those simulations give organizations more confidence in quantum computing platforms by allowing them to compare results. However, quantum computers are now approaching a level where at some point between 2022 and 2023 that will no longer be possible, Honeywell Quantum Solutions president Tony Uttley said.

Honeywell has pursued an approach to quantum computing that differs from those of rivals by focusing its efforts on a narrower range of more stable qubits. Each system is based on a trapped-ion architecture that leverages numerous individual charged atoms (ions) to hold information. It then applies electromagnetic fields to hold (trap) each ion in a way that allows it to be manipulated and encoded using laser pulses.

The company makes its quantum computers available via a subscription to a cloud service and counts BMW, DHL, JP Morgan Chase, and Samsung among its customers. Systems residing outside of Boulder, Colorado and Minneapolis are made available to customers for up to two weeks at a time before being taken offline for two weeks to add additional capacity.

Subscriptions for the System Model H1 service are currently sold out, and each Honeywell quantum computing customer has previously tried to employ a different platform before switching to Honeywell, Uttley said. The company is now moving toward making a third-generation System Model H2 service available that will offer higher levels of unspecified quantum volume, Uttley added.

Honeywell has committed to delivering a tenfold increase in quantum volume every five years. The company has been able to deliver a fourfold increase in the amount of quantum volume it can make available in the last five months alone, Uttley said.

Quantum computers can process bits that have a value of both 0 and 1 at the same time, which makes them more powerful than conventional computing platforms. Advances in quantum computing, however, will by no means signal the demise of conventional computers, Uttley added. Instead, its becoming apparent that quantum computers and conventional computers are simply going to be better suited to running different classes of workloads, Uttley said.

These systems will run side by side for decades, Uttley added. Conventional computing platforms are not going to be replaced anytime soon.

Quantum computers, however, are better suited to addressing complex computational challenges involving chemistry, routing optimizations using, for example, logistics and traffic management applications, and even the training of AI models. In the latter case, a quantum computer can identify the starting point for the training of an AI model that would then be completed by a conventional computer. Other more intractable problems involving, for example, applications for ways to reduce the level of carbon in the atmosphere are only feasible to run on a quantum computing platform.

It may still be a while before quantum computing delivers on its full promise, but while the way quantum systems work may not be widely understood, there is now no turning back.

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Honeywell says quantum computers will outpace standard verification in 18 to 24 months - VentureBeat

Quantum computer is fundamentally different than conventional & supercomputers and use the technology based on quantum phenomena. Unlike classical computers, it uses quantum bits (qubits) to process the data. In addition, quantum computing performs complex calculations proficiently when compared with classical computers and this factor majorly fuels the growth of the enterprise quantum computing market application. Furthermore, it finds its application in aerospace & defense, BFSI, healthcare & life science, energy & utilities, manufacturing, IT & telecom, and other industries.

The global Quantum Computing market is expected to expand at a CAGR of +26% over the forecast period 2019-2025.

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Top Key Vendors in Market:

D-Wave Systems Inc. (Canada), QX Branch (US), International Business Machines Corporation (US), Cambridge Quantum Computing Limited (UK), 1QB Information Technologies (Canada), QC Ware, Corp. (US), StationQ- Microsoft (US), Rigetti Computing (US), Google Inc. (US), River Lane Research (US)

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Global Quantum Computing Market Research Report 2019-2025

Chapter 1: Industry Overview

Chapter 2: Quantum Computing Market International and China Market Analysis

Chapter 3: Analysis of Revenue by Classifications

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Explore why Quantum Computing Market is thriving worldwide by 2025 with top key players like D-Wave Systems Inc. (Canada), QX Branch (US),...

Julie Appleby, Kaiser Health News

Sorry Dr Fauci and other fearmongers, new study shows vaccines and naturally acquired immunity DO effectively neutralize COVID variants. Good news for everyone but bureaucrats and petty tyrants!

Sen. Rand Paul in a tweet, March 21, 2021

That Sen. Rand Paul of Kentucky often disagrees with infectious-disease expert Dr. Anthony Fauci is well known.

This story was produced in partnership withPolitiFact. It can be republished for free.

Recently, the pair clashed at a Senate hearing when Paul, a Republican, argued against mask recommendations for people who have had covid-19 or have been vaccinated against it.

At the hearing, Fauci, President Joe Bidens chief medical adviser, pushed back against Pauls characterization of wearing masks as theater. Continued caution is advised, Fauci said, as scientists study the new variants now circulating in the U.S. and other countries.

Paul, an eye doctor by training, continued the squabble a few days later, calling out Fauci in a tweet, pointing to a study that he said shows vaccines and naturally acquired immunity DO effectively neutralize COVID variants.

The tweet linked to a study published online at the JAMA Network, a family of specialty medical journals.

We reached out to Pauls office for additional sources for his tweet but did not receive a reply.

So, we asked the experts: Are covid variants effectively neutralized by vaccines or natural immunity conferred on people who recover from the illness?

In short, the research cited by Paul does show good blood levels of neutralizing antibodies against at least some of the current variants following infection or vaccination. But theyre not the whole story.

Mehul S. Suthar, an author of the study Paul cited, said the results are encouraging but should not be seen as all-encompassing: Our interpretation is that our study looks at one aspect of immune response, antibodies.

Small Samples. Big Questions.

Neutralizing antibodies are important because they can block the ability of a virus like the one that causes covid to infect cells. But the body also has other defenses. T cells, for example, can be spurred by infection or vaccination, Suthar said, although the study was not designed to look at those.

For the study, researchers gathered blood samples from 40 people who were in the hospital with covid or had recovered from it. From the National Institutes of Health, they also received blood samples drawn from 14 people who had gotten both doses of the Moderna vaccine, said Suthar, an assistant professor at Emory Universitys vaccine center.

Then they ran tests on those samples against the original SARS-CoV-2 virus and three variants, including the one dubbed B.1.1.7, which first appeared in the United Kingdom and is now circulating widely in the U.S.

They wanted to know: Did antibodies produced by being infected or vaccinated neutralize B.1.1.7?

We are lucky with B.1.1.7 that our antibodies appear to work well against this virus, Suthar said.

However, as with any study, there are caveats. For one thing, the results were based on a small number of samples. And the analysis did not include other variants of concern, such as the ones that emerged in South Africa and Brazil, which limits the ability to draw broad conclusions.

Finally, antibodies are just one measure of potential protection against disease. Laboratory research measuring antibodies indicates that some immunity is created by both illness and vaccination, but the strength and longevity of that protection the effectiveness in the real world is a separate question. Thats partly because the ideal level of neutralizing antibodies needed for protection is not known and other immune protections, such as T cells, arent measured.

Also, in the real world, other factors such as the variant a person is exposed to, and the presence of other mitigating factors, including masks and good ventilation can make a difference.

Part of the reason that real-world data are so important is looking at the whole picture of immunity, said Gigi Gronvall, a senior scholar at Johns Hopkins Bloomberg School of Public Health. Also, with the level of community transmissions of disease, I would be concerned that there will be more variants that emerge.

Nuance Matters

Pauls tweet taking aim at what he sees as an overcautious approach by public health experts doesnt capture that type of nuance, nor does it reference studies on the other emerging variants.

Blanket assertions made by non-scientific experts are not going to help, said Gronvall.

Dr. Jesse Goodman, professor of medicine and a specialist in infectious diseases at Georgetown University, agreed.

Its wrong to declare victory and say theres no problem with variants and that everyone previously infected will be fine, said Goodman, who served as chief scientist of the Food and Drug Administration under the Obama administration.

Viruses naturally mutate as they replicate. So its not surprising that the coronavirus has done so. Several variants have emerged, including home-grown ones from California and New York.

Lab tests on blood samples from vaccine trial participants in South Africa showed lower levels of neutralizing antibody production, possibly related to the variant circulating there.

How big a difference the lower levels measured in those samples make isnt yet known.

Levels are still high and could effectively neutralize the virus, Fauci wrote in an editorial published Feb. 11 in JAMA.

Even so, clinical trials used to test covid vaccines before they were approved for emergency use showed lower efficacy when tested in areas where the South African variant was circulating.

We expect vaccines and prior infection to offer significant protection against variants that are closely related, said Goodman. But as they become more genetically different like the South African one that protection could go down.

The main goal of the vaccines is to prevent hospitalization and death, and all the vaccines in use in the U.S. appear to substantially reduce the risk of hospitalization and death from covid, according to research.

Even if the current vaccines may not be perfect, they do appear to prevent more severe outcomes, Goodman said.

Dont assume, as Pauls tweet implies, that recovering from covid or getting vaccinated means zero risk of infection.

For one thing, reinfection is rare but can occur.

Goodman pointed to a recent study conducted in Denmark showing that a small percentage (0.65%) of people who tested positive for covid in the spring fell ill again.

People should not presume that even if they had the vaccine or were previously infected that theres no future risk, Goodman said.

Even though no vaccine is 100% effective, Gronvall at Hopkins said not to use that as an excuse to avoid inoculation.

The vaccines appear to be great, she said. Get one when you can.

Our Ruling

Paul is correct that the JAMA study showed vaccination or previous infection appeared, based on a small sample of people, to help neutralize the virus. However, he left out important details that make his position an oversimplification of a complicated issue.

The study considered only one variant the one that emerged in the U.K. and did not include an analysis of other types now circulating, or the potential for additional variants that could emerge. Also, the type of antibody studied is just one factor in protecting against disease, and just what those levels of neutralizing antibodies measured in a laboratory experiment may mean in the real world is not known.

So, for those reasons, we rate the senators statement Half True.

Telephone interview with Mehul S. Suthar, assistant professor at the Emory Vaccine Center, March 22, 2021

Telephone interview with Gigi Gronvall, senior scholar at Johns Hopkins Center for Health Security and associate professor in the environmental health and engineering department at Johns Hopkins Bloomberg School of Public Health, March 23, 2021

Telephone interview with Jesse Goodman, professor of medicine at Georgetown University and former chief scientist of the Food and Drug Administration, March 24, 2021

JAMA Network, Neutralizing Antibodies Against SARS-CoV-2 Variants After Infection and Vaccination, March 19, 2021

CNN Politics, Masks Are Not Theater, Fauci Tells Sen. Rand Paul in Hearing Exchange, March 18, 2021

The New England Journal of Medicine, Neutralizing Activity of BNT162b2-Elicited Serum, March 8, 2021

The New England Journal of Medicine, Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine, March 17, 2021

Yale Medicine, Comparing the COVID-19 Vaccines: How Are They Different?, updated March 25, 2021

Fast Company, Can I Get Covid-19 Twice? New Lancet Study Offers Insight on Reinfection Rates, March 22, 2021

JAMA Network, SARS-CoV-2 Viral Variants Tackling a Moving Target, editorial, Feb. 11, 2021

View post:
In His Continued Sparring With Fauci, Sen. Rand Paul Oversimplified the Science - Kaiser Health News

Sorry Dr Fauci and other fearmongers, new study shows vaccines and naturally acquired immunity DO effectively neutralize COVID variants. Good news for everyone but bureaucrats and petty tyrants!

Sen. Rand Paul in a tweet, March 21, 2021

That Sen. Rand Paul of Kentucky often disagrees with infectious-disease expert Dr. Anthony Fauci is well known.

This story was produced in partnership with PolitiFact. It can be republished for free.

Recently, the pair clashed at a Senate hearing when Paul, a Republican, argued against mask recommendations for people who have had COVID-19 or have been vaccinated against it.

At the hearing, Fauci, President Joe Bidens chief medical adviser, pushed back against Pauls characterization of wearing masks as theater. Continued caution is advised, Fauci said, as scientists study the new variants now circulating in the U.S. and other countries.

Paul, an eye doctor by training, continued the squabble a few days later, calling out Fauci in a tweet, pointing to a study that he said shows vaccines and naturally acquired immunity DO effectively neutralize COVID variants.

The tweet linked to a study published online at the JAMA Network, a family of specialty medical journals.

We reached out to Pauls office for additional sources for his tweet but did not receive a reply.

So, we asked the experts: Are COVID variants effectively neutralized by vaccines or natural immunity conferred on people who recover from the illness?

In short, the research cited by Paul does show good blood levels of neutralizing antibodies against at least some of the current variants following infection or vaccination. But theyre not the whole story.

Mehul S. Suthar, an author of the study Paul cited, said the results are encouraging but should not be seen as all-encompassing: Our interpretation is that our study looks at one aspect of immune response, antibodies.

Neutralizing antibodies are important because they can block the ability of a virus like the one that causes COVID to infect cells. But the body also has other defenses. T cells, for example, can be spurred by infection or vaccination, Suthar said, although the study was not designed to look at those.

For the study, researchers gathered blood samples from 40 people who were in the hospital with COVID or had recovered from it. From the National Institutes of Health, they also received blood samples drawn from 14 people who had gotten both doses of the Moderna vaccine, said Suthar, an assistant professor at Emory Universitys vaccine center.

Then they ran tests on those samples against the original SARS-CoV-2 virus and three variants, including the one dubbed B.1.1.7, which first appeared in the United Kingdom and is now circulating widely in the U.S.

They wanted to know: Did antibodies produced by being infected or vaccinated neutralize B.1.1.7?

We are lucky with B.1.1.7 that our antibodies appear to work well against this virus, Suthar said.

However, as with any study, there are caveats. For one thing, the results were based on a small number of samples. And the analysis did not include other variants of concern, such as the ones that emerged in South Africa and Brazil, which limits the ability to draw broad conclusions.

Finally, antibodies are just one measure of potential protection against disease. Laboratory research measuring antibodies indicates that some immunity is created by both illness and vaccination, but the strength and longevity of that protection the effectiveness in the real world is a separate question. Thats partly because the ideal level of neutralizing antibodies needed for protection is not known and other immune protections, such as T cells, arent measured.

Also, in the real world, other factors such as the variant a person is exposed to, and the presence of other mitigating factors, including masks and good ventilation can make a difference.

Part of the reason that real-world data are so important is looking at the whole picture of immunity, said Gigi Gronvall, a senior scholar at Johns Hopkins Bloomberg School of Public Health. Also, with the level of community transmissions of disease, I would be concerned that there will be more variants that emerge.

Pauls tweet taking aim at what he sees as an overcautious approach by public health experts doesnt capture that type of nuance, nor does it reference studies on the other emerging variants.

Blanket assertions made by non-scientific experts are not going to help, said Gronvall.

Dr. Jesse Goodman, professor of medicine and a specialist in infectious diseases at Georgetown University, agreed.

Its wrong to declare victory and say theres no problem with variants and that everyone previously infected will be fine, said Goodman, who served as chief scientist of the Food and Drug Administration under the Obama administration.

Viruses naturally mutate as they replicate. So its not surprising that the coronavirus has done so. Several variants have emerged, including home-grown ones from California and New York.

Lab tests on blood samples from vaccine trial participants in South Africa showed lower levels of neutralizing antibody production, possibly related to the variant circulating there.

How big a difference the lower levels measured in those samples make isnt yet known.

Levels are still high and could effectively neutralize the virus, Fauci wrote in an editorial published Feb. 11 in JAMA.

Even so, clinical trials used to test COVID vaccines before they were approved for emergency use showed lower efficacy when tested in areas where the South African variant was circulating.

We expect vaccines and prior infection to offer significant protection against variants that are closely related, said Goodman. But as they become more genetically different like the South African one that protection could go down.

The main goal of the vaccines is to prevent hospitalization and death, and all the vaccines in use in the U.S. appear to substantially reduce the risk of hospitalization and death from COVID, according to research.

Even if the current vaccines may not be perfect, they do appear to prevent more severe outcomes, Goodman said.

Dont assume, as Pauls tweet implies, that recovering from COVID or getting vaccinated means zero risk of infection.

For one thing, reinfection is rare but can occur.

Goodman pointed to a recent study conducted in Denmark showing that a small percentage (0.65%) of people who tested positive for COVID in the spring fell ill again.

People should not presume that even if they had the vaccine or were previously infected that theres no future risk, Goodman said.

Even though no vaccine is 100% effective, Gronvall at Hopkins said not to use that as an excuse to avoid inoculation.

The vaccines appear to be great, she said. Get one when you can.

Paul is correct that the JAMA study showed vaccination or previous infection appeared, based on a small sample of people, to help neutralize the virus. However, he left out important details that make his position an oversimplification of a complicated issue.

The study considered only one variant the one that emerged in the U.K. and did not include an analysis of other types now circulating, or the potential for additional variants that could emerge. Also, the type of antibody studied is just one factor in protecting against disease, and just what those levels of neutralizing antibodies measured in a laboratory experiment may mean in the real world is not known.

So, for those reasons, we rate the senators statement Half True.

KHN (Kaiser Health News) is a national newsroom that produces in-depth journalism about health issues. Together with Policy Analysis and Polling, KHN is one of the three major operating programs at KFF (Kaiser Family Foundation). KFF is an endowed nonprofit organization providing information on health issues to the nation.

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Analysis: In his continued sparring with Fauci, Sen. Rand Paul oversimplified the science - Grand Forks Herald