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Washington (CNN) -- President Obama weighed in on the Scottish independence referendum Wednesday night when he tweeted in favor of a united UK.

But for the most part, faced with the prospective divorce of its closest friend, the United States is following the advice column carefully: don't take sides, keep your opinions to yourself, and avoid getting dragged into the fray.

The complicating factor in this potential split? One side has a nuclear arsenal. Who gets custody of that?

Thursday's independence referendum in Scotland, and with it the possible split of the 300-year-old United Kingdom, could have consequences big and small, including in the United States. The "special relationship" heralded by presidents and prime ministers for decades would be fundamentally altered, though American officials refuse to speculate in which ways.

As British Prime Minister David Cameron said on Tuesday, a "yes" result on independence would amount to a "painful divorce" between Scotland and the rest of Great Britain, not a "trial separation."

Scotland divided over independence

Scotland divided over independence

Scotland divided over independence

Scotland divided over independence

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Obama picks a side