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Dr. Jeremiah Stamler has a little problem at work. You know the kind: that checklist item that you cant quite seem to check, the one part of the big project that you havent yet nailed down.

You cant slam the door shut on the work until you get answers.

Stamler knows the problem is out there, just waiting for him. And, frankly, thats just the kind of thing he thrives on.

Jerry Stamler is a professor emeritus and active research doctor at the Northwestern University Feinberg School of Medicine who recently turned 100 years old.

His problem is cheese.

Stamlers specialty is preventive medicine in fact, he helped invent the field. He did pioneering research into the causes of heart disease, and coined the term risk factors to describe circumstantial and genetic contributors that increase the risk of cardiovascular disease. While working for Richard J. Daleys Public Health Department in the 1960s, he developed the Heart Disease Control Program, aimed at educating the public and bringing focus to issues the city still grapples with, such as the availability of healthy food in poor neighborhoods.

Hes an early adopter of whats known today as the Mediterranean diet, and his own best advertisement, a long-living testament to the lifestyle changes he advocates.

Currently, hes one of only a tiny handful of scientists over age 90 to have an active NIH grant for research.

Oh, and hes a WWII veteran and is partially responsible for the demise of the notorious House Un-American Activities Committee.

We have immense amounts of things we should be grateful to Dr. Stamler for, says Dr. Donald Lloyd-Jones, chair of the Department of Preventive Medicine at Northwestern, because hes improved our health as a nation and a world, but hes also affected our society.

Lloyd-Jones points out that Stamler, who founded the department Lloyd-Jones now presides over, has retained 110% of his mental acuity. Hes forgotten more than I will ever know, and I dont think hes forgotten very much.

But, aside from being an obvious outlier in the healthy-habits-plus-great-genes department, the record of Stamlers life reveals another core characteristic that clearly fuels him. Hes charming, and smart, but he wont back down. Not for anything. Not for big food companies or basic human intransigence or even Congress. Not for the toll age takes, not even for time.

He has made standing up for things his stock-in-trade.

I think its a measure of his character, says Lloyd-Jones. Its remarkable. Hes my hero.

Stamler was born in Brooklyn in 1919, and grew up in West Orange, N.J., the child of Russian immigrants. From an early age, he was suspicious of mass-market food. The loaf of white bread is anathema, he says. My father got to this country, saw the white bread and was ready to get back on the boat and go home! Instead, he grew up with hearty rye breads and got an early start eating whole grains. Other healthy habits came easy, he says: I never liked butter. I dont know why. It mustve been something in the blood, intuitive.

After medical school, he did what most of his contemporaries were doing and entered the Army. Near the end of World War II, he was sent overseas: To Bermuda, he says. So I spent a lovely year in Bermuda, my wife came with me, and it was very nice. Shortly thereafter, the war ended and Stamler, like thousands of other GIs, headed home to launch the next phase of his life.

He knew he wanted that life to be in research, and in 1947, found a place to pursue that work, taking a position at Michael Reese Hospital in Bronzeville under pioneering cardiology researcher Dr. Louis Katz. Dr. Katz told me, Why the hell do you want to go into research? says Stamler. You never win. When you first discover something, people will say I dont believe it. Then you do more research and verify it and theyll say, yes, but Then you do more research, verify it further and theyll say, I knew it all the time. And he was right.

Undeterred, Stamler and his first wife, Rose, who trained as a sociologist but went on to become a major researcher in the fields of cardiovascular disease and hypertension in her own right, moved to Chicago in 1947. They offered me a $200-a-month fellowship, Stamler says. In those days, that was a fortune.

Stamlers research involved examining the effects of cholesterol and other factors suspected as drivers of cardiovascular disease. I was always interested in the heart artery problem. Why did human beings with diabetes get more heart artery disease? Whats the relation of habitual lifestyle, fat intake, saturated fat intake, cholesterol intake, salt intake, with cardiovascular disease. The interplay between multiple factors. And of course we were all interested in tobacco even way back then.

Stamler studied his theories on animals. I was feeding cholesterol to chickens, he says. We could test everything that we suspected might have an impact, except smoking. And over time, he helped discover and confirm many of the things we now take for granted: High cholesterol and high blood pressure are linked to cardiovascular disease.

Stamlers interest in these issues didnt stop at the merely scientific, however. He had long been interested in social causes he and Rose had met at student meetings during WWII, while he was still in college, and her work leaned strongly into social justice. He realized that his work had vast implications in the world outside the laboratory. From 1948 on, as our work accelerated, he says, we were more inclined to translate our findings into recommendations for the public.

That approach began to earn him a few enemies. Here in Chicago, we had the North American Meat Institute, they were barking at me all the time. They had a very simple view: Why dont you do research, write papers, publish them and shut up? We didnt feel that was an appropriate posture for people doing research on a scientific problem of great public health importance, to do the research and then bury it. What the hell is the point?

Big tobacco, big food companies and other interest groups werent too happy about Stamlers findings either. He didnt care. I began to find the best ways to express all this to the public, and we decided that the best way is the risk factor concept, he says. A set of well-defined traits, easily measured, frequently occurring, which when present, particularly in combination, are greatly associated with increased risk.

Risk factors, which represented something the public could understand and act to change, changed the face of how Americans thought about cardiovascular health. The question was, what happens when you modify them, control them, lower them? Stamler says. Does the cigarette smoker at age 60, after more than 40 years of smoking, benefit from quitting smoking and lowering cholesterol? The answer is, it isnt too late.

Stamler was driven by a desire to see that knowledge put into practice by the public. Its a very important message, he says. From a practical point of view, its the only message.

In 1958, Stamler brought that activist approach to public health to city government, taking a position in Daleys Department of Public Health. I rolled up my sleeves and went formally to work, he says. A different kind of work. Quite different from feeding cholesterol to chickens.

Reluctantly, he gave up animal research and turned his attention to the pressing concerns of the citys health. We started with rheumatic fever prevention in kids, he says. We developed a hypertension control program, coronary prevention evaluation program, all right there in Mr. Daleys Health Department. He actually used a picture of me with one of the participants in the programs in one of his political campaigns, to show how up-to-date and modern his administration was.

Stamler also looked to tackle Chicagos diet: First and foremost, we worked to improve the mix of foods that were readily available in the supermarket. We encouraged broiling rather than frying, roasting on a rotisserie rather than frying, modest portion sizes.

Chicagos legendary steakhouses? They didnt exactly fit Stamlers program.

It may be OK to victimize a tourist by selling him a 16-ounce steak, he says, but for the natives, lets make it a 4- or 5-ounce steak. Lets encourage fish and seafood, vegetables and fruits, whole grains. Not that were indifferent to the outside, but we feel a first responsibility to locals.

But it wasnt steakhouses or even food lobbyists who posed Stamlers next challenge. In 1965, he was called before the House Un-American Activities Committee, a congressional committee aimed at ferreting out suspected communist sympathizers in America. The committee was known for subpoenaing a range of people, from the entertainment industry, academia and other spheres of public life.

They had informants who told them who to call, says Tom Sullivan, an attorney with Jenner & Block who worked on Stamlers HUAC case, and the people took the Fifth Amendment and that was the end of it. It ruined many lives and employment and wreaked havoc. The consequences for refusing to answer the committees questions was blacklisting, and in Stamlers case, Sullivan says, Mayor Daley would have fired him immediately.

Stamler chose not to exercise a right against self-incrimination, instead choosing not to answer the committees questions to him by challenging its constitutional right to do so. Sullivan and his team filed suit against the committee on behalf of Stamler and his colleague, Yolanda Hall, who worked as a nutritionist in his department and was also an outspoken activist on issues such as fair housing and civil rights. The committee found the pair in contempt of Congress. The clients were facing years in jail for contempt of Congress, says Sullivan, and Jerry Stamler decided he was willing to take that chance, to make this a test case.

Litigation followed, for 8 1/2 years, during which Stamler continued to champion public health but rarely spoke publicly about the court battle. In late 1973, the case settled, with the committee, which had begun to lose steam, backing down and Stamlers side agreeing to withdraw its complaint.

In 1975, HUAC was disbanded. The case, says Sullivan, was the decisive factor in ending it.

Those who know Stamler best say the story isnt out of character. He has a mantra, says Lloyd-Jones, just apply firm, steady pressure. When his scientific discoveries or medical recommendations meet resistance, Lloyd-Jones says, his response is always the same: Keep smiling. But dont back down. He knows that if you apply firm, steady pressure over time, the data will win the day. If we make sure our assertions are grounded in the very best science, the truth will out.

In 1972, Stamler was appointed as the founding director of the Department of Community Health and Preventive Medicine at Northwestern, where his research continued, and he took on the role of mentor to a stream of new cardiologists and researchers.

The work has never let up, though Stamler has decided where to draw the line in one arena: He sort of stopped advancing in his tech use at fax machines, says Lloyd-Jones, so when we send him papers to read, we email them to his assistant, they print them out, he takes the hard copy, he marks them up extensively in pen, and he faxes them back. Currently, hes working with a team on metabolomics, the study of products created by the bodys metabolic processes.

Those faxed notes, Lloyd-Jones says, are sharp as ever. Hes really at his core a scientist. Hes always about taking the data and what it is giving you and not over-interpreting it.

Stamler sticks to his guns at home as well. We eat a lot of egg whites in this house, he says. And Im not saying that to make nice with the Egg Board. I like hard-boiled egg white with tomato in a good sandwich with whole wheat bread.

Diet is key to good health, he says, and happiness is important too. Stamler shares homes in New York, Italy and Chicago with his second wife, Gloria, a childhood friend with whom he reconnected after Rose died in 1998.

Though age has robbed him of mobility and he now uses a wheelchair, Stamler says he has one answer for people who wonder whether hell retire: No.

He loves it, says Gloria.

And, of course, hes not quite finished. If you think about it, he says, I should have retired about 30 years ago. But Ive kept going, on the basis that theres still some fascinating stuff out there that we havent touched very well.

Like, for instance, cheese a supposed villain when it comes to heart health. There may be more there than meets the eye, says Stamler. Its too early to say. People say Why are you still working? Its intriguing questions like that. Whats the bottom line with cheese? It just keeps you intrigued and going on.

For the scientist, at least, cheese has a benefit. Maybe even, at this point, a touch of symbiosis.

Im annoyed with my ignorance about cheese, Stamler says, contemplating his next move. I havent taken the time to get that clear. It sounds simple, but doing it well is a big job.

Read more from the original source:
At age 100, the father of preventive medicine is still going strong as living proof that he was right all along - yoursun.com