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Political newcomer Seth Moulton is setting his sights on Republican Richard Tisei in the state's 6th Congressional District, having pulled off the stunning defeat of nine-term incumbent U.S. Rep. John Tierney in a bitter Democratic primary contest.

Tierney is the first sitting Massachusetts congressman to lose a primary since 1992, when former U.S. Rep. Marty Meehan beat then-incumbent Chester Atkins in the Democratic primary.

Moulton, a former Marine and Iraq war veteran from Salem, will face Tisei in November. He credited his win Tuesday in part on voter frustration with Congress.

"It's time for a new approach to end the gridlock in Washington," Moulton told supporters Tuesday night. "It's not enough to blame the Republicans for the lack of progress at a time when our country faces so many challenges. And it's cynical to think we must accept it."

Tierney, in a brief concession speech, said he was proud of "an amazing 18 years" in office.

Moulton ran a well-financed campaign, suggesting Tierney had been ineffective in Congress.

Tierney is the fourth House incumbent and first Democrat to lose a primary this year. He joins Republican Reps. Kerry Bentivolio of Michigan, Eric Cantor of Virginia, the former majority leader, and Ralph Hall of Texas on the House casualty list.

During much of the primary Tierney had focused his attention on Tisei.

Then, late in the primary, Tierney launched a campaign ad linking Moulton to Republicans who support gun rights and oppose abortion rights. The ad focused on money the Moulton campaign received from the White Mountain PAC, which is affiliated with former U.S. Sen. Judd Gregg, a New Hampshire Republican.

Moulton said the ad showed that Tierney believed he was a serious challenger.

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Democrat Moulton Sets Sights on Congressional Seat