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WASHINGTON Hillary Rodham Clinton can claim a piece of the victory if the U.S. and other world powers ultimately complete a final nuclear deal with Iran.

She will own a piece of the failure if the negotiations collapse or produce a weak deal.

Her statement after Thursday's tentative agreement suggests the soon-to-be Democratic candidate for president knows those are her stakes.

She called the framework "an important step," while cautioning that "the devil is always in the details."

"The onus is on Iran and the bar must be set high," said Clinton, who helped lay the groundwork for the diplomacy with Iran as President Barack Obama's first secretary of state. "There is much to do and much more to say in the months ahead, but for now diplomacy deserves a chance to succeed."

The issue will figure prominently in the foreign policy debate of the 2016 presidential campaign. Nearly all the expected GOP candidates said the outline agreement was dangerous to U.S. interests.

"This attempt to spin diplomatic failure as a success is just the latest example of this administration's farcical approach to Iran," said Florida Sen. Marco Rubio. He is likely to make foreign policy a centerpiece of his candidacy.

But Clinton occupies a unique space on the nuclear issue because of her role in Obama's Cabinet. She sent a close adviser, Jake Sullivan, to participate in the secret talks with Iran that led to the start of the international negotiations over the country's nuclear ambitions.

Clinton is also navigating delicate ties with Israel and the American Jewish community, an influential group of voters and donors. Israeli Prime Minister Benjamin Netanyahu, a fierce critic of the Obama administration's outreach to Iran, described the framework deal as a threat to "the very survival" of his nation.

"I don't know how you can maneuver all aspects of this politically," said Ray Takeyh, a senior fellow for Middle Eastern studies at the Council on Foreign Relations. "You can be supportive and skeptical. I suspect that's the direction."

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High political stakes for Hillary Clinton no matter the outcome of Iran nuclear agreement

NEW YORK (CNN) -

The second time around, Hillary Clinton is downsizing.

As she and a coterie of advisers prepare to launch her presidential campaign, their work is guided by a new set of humble principles: No big crowds. Few soaring rallies. Less mention of her own ambitions. And extinguish the air of inevitability propelling her candidacy.

The long and winding prelude to her announcement is nearly over, according to aides, and the start of her second bid for the White House is likely only days away. Top Democratic activists in the early-voting states of Iowa and New Hampshire privately say they have been placed on alert that Clinton will soon be on her way.

The specific moment she jumps into the race remains a closely-guarded secret, even inside the crowded corridors of her small office suite in Manhattan, which new aides have descended upon to build the operation. Only a handful of confidantes actually know the precise time Clinton will pull the trigger -- first on social media -- yet aides have been instructed to be ready from Monday forward.

But her campaign strategy has crystallized: She will devote considerable time and attention to on-the-ground footwork in Iowa and New Hampshire. She intends to make less frequent stops in Nevada and South Carolina. Together, those four states kick off the nominating contest early next year and will help determine how warmly Democrats embrace her candidacy.

The early pieces of her strategy are starting to come into sharper view as the announcement nears. One of the most noticeable differences from her first campaign, according to more than a dozen people close to the Clintons, is a concerted effort to try and make her candidacy seem far less focused on her winning than on listening to the concerns of voters.

"The early caucus and primary states give her an opportunity to visit with folks in small, more intimate settings, where they will learn a lot about her and she will learn a lot from them," Tom Vilsack, the agriculture secretary and former Iowa governor, who served as a national chairman of her 2008 campaign, told CNN.

Putting in time in Iowa

Over dinner and drinks one night last week at Baratta's, a cozy Italian restaurant in Des Moines, two top visiting Clinton strategists listened as supportive Iowa activists issued a stark warning: Some Democrats are far less enthused about her candidacy than others. After placing third in the Iowa caucuses in 2008, they said she must ask for every vote as well as being willing to run a gauntlet of small events and take part in grueling campaign sessions across the state.

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Activists in Iowa, N.H. prepped for Clinton's arrival

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